The unity of knowledge was once presupposed. In antiquity and through much of the early modern period, philosophia naturalis encompassed what we now separate as science and philosophy. Thinkers like Descartes treated physics, metaphysics, and method within a single continuum; Leonardo embodied the seamless flow of artistic observation, engineering, and inquiry. Art, science, and speculative thought were not rival domains but facets of the same pursuit of understanding the world and our place in it. The divergence accelerated in the 19th century. Around 1833, at a meeting of the British Association for the Advancement of Science, poet Samuel Taylor Coleridge clashed with emerging scientific professionals. William Whewell coined "scientist" as a more modest term than "natural philosopher," marking a linguistic and cultural shift toward specialization and experimentation over broader philosophical framing. C.P. Snow later formalized this as the "Two Cultures" problem in 1959: literary intellectuals versus scientists, with mutual incomprehension hindering solutions to human problems. By the 19th–20th centuries, further fragmentation occurred—humanities versus natural sciences, then sub-disciplines proliferating. Philosophy was increasingly relegated to the humanities, while science pursued empirical precision and technological mastery. Art often retreated into subjective expression or critique, sometimes scorning the "disenchanting" effects of mechanistic explanation.